Episode 80: Big Picture of Propofol

2 min readAug 12, 2021

How can we appropriately use one of our “favorite” agents if we do not understand the big picture of propofol?

Critical pharmacist expert and host of the podcast, ER-Rx: An ER + ICU Podcast, Adis Keric, BCPS, BCCP, breaks it down for us.

Welcome | ER-Rx

Recent Reviews/ Comments "I love listening to this podcast because I can listen to 1 or 2 on my way to work and it…

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References:

Anesthesia with Propofol Induces Insulin Resistance Systemically in Skeletal and Cardiac Muscles…

Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and…

www.ncbi.nlm.nih.gov

Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes

Propofol infusion syndrome (PRIS) is a rare but lethal condition caused by prolonged propofol overdose [ 1- 3]. The…

www.ncbi.nlm.nih.gov

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to…

Low-grade myotoxicity can be associated with prolonged (weeks) exposure to propofol in the ICU. ICU patients in our…

www.ncbi.nlm.nih.gov

Propofol blocks human skeletal muscle sodium channels in a voltage-dependent manner - PubMed

Voltage-gated sodium channels mediate the initiation and propagation of action potentials along the sarcolemma. Results…

pubmed.ncbi.nlm.nih.gov

https://journals.lww.com/ejanaesthesiology/fulltext/2007/01000/severe_myalgia_associated_with_propofol_sedation.16.aspx

Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with…

doi: 10.1161/01.STR.0000128418.17312.0e. 1 Department of Infectious Diseases, M5132, University Hospital…

pubmed.ncbi.nlm.nih.gov

Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous…

1 From the Department of Surgical Intensive and Intermediate Care, and Department of Anesthesiology, University…

pubmed.ncbi.nlm.nih.gov

Suppression of Central Nervous System Sodium Channels by Propofol

Received from the Department of Anesthesiology, Cornell University Medical College, New York, New York. Submitted for…

pubs.asahq.org

Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability…

doi: 10.1186/s40635-016-0083-4. 1 Department of Anesthesiology and Intensive Care Medicine, Campus Virchow-Klinikum and…

pubmed.ncbi.nlm.nih.gov

Episode 80: Big Picture of Propofol

Welcome | ER-Rx

Recent Reviews/ Comments "I love listening to this podcast because I can listen to 1 or 2 on my way to work and it…

Anesthesia with Propofol Induces Insulin Resistance Systemically in Skeletal and Cardiac Muscles…

Hyperglycemia together with hepatic and muscle insulin resistance are common features in critically ill patients, and…

Cytotoxicity of propofol in human induced pluripotent stem cell-derived cardiomyocytes

Propofol infusion syndrome (PRIS) is a rare but lethal condition caused by prolonged propofol overdose [ 1- 3]. The…

Does prolonged propofol sedation of mechanically ventilated COVID-19 patients contribute to…

Low-grade myotoxicity can be associated with prolonged (weeks) exposure to propofol in the ICU. ICU patients in our…

Propofol blocks human skeletal muscle sodium channels in a voltage-dependent manner - PubMed

Voltage-gated sodium channels mediate the initiation and propagation of action potentials along the sarcolemma. Results…

Cerebral blood flow and metabolism during infusion of norepinephrine and propofol in patients with…

doi: 10.1161/01.STR.0000128418.17312.0e. 1 Department of Infectious Diseases, M5132, University Hospital…

Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous…

1 From the Department of Surgical Intensive and Intermediate Care, and Department of Anesthesiology, University…

Suppression of Central Nervous System Sodium Channels by Propofol

Received from the Department of Anesthesiology, Cornell University Medical College, New York, New York. Submitted for…

Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability…

doi: 10.1186/s40635-016-0083-4. 1 Department of Anesthesiology and Intensive Care Medicine, Campus Virchow-Klinikum and…

Written by Walking Home From The ICU